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Volume 31 , Issue 4
July/August 2011
Pages 335-342

A Retrospective Consecutive Case Series Using Mineralized Allograft Combined with Recombinant Human Platelet-Derived Growth Factor BB to Treat Moderate to Severe Osseous Lesions

Paul S. Rosen, DMD, MS/Nicholas Toscano, DDS, MS/Daniel Holzclaw, DMD, MS/Mark A. Reynolds, DDS, PhD

PMID: 21837299
DOI: 10.11607/prd.00.0995

This retrospective case series reports on the use of freeze-dried bone allograft (FDBA) combined with a purified recombinant protein of platelet-derived growth factor BB (PDGF-BB) for the treatment of periodontal intraosseous defects in 50 consecutive patients. The mean pretreatment measurements for clinical attachment level and probing depth were 7.9 ± 1.6 mm and 7.8 ± 1.4 mm, respectively. At 6 months, mean clinical attachment level was 3.9 ± 1.4 mm, reflecting an improvement of 4.1 ± 1.3 mm, whereas mean probing depth was reduced to 3.0 ± 1.2 mm, corresponding to a reduction of 4.8 ± 1.4 mm. These clinical results indicate that the combined use of FDBA and PDGF-BB can lead to substantial improvements in clinical parameters. (Int J Periodontics Restorative Dent 2011;31:335–342.)

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